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Helmut Hanenberg Selected Research

Fanconi Anemia (Fanconi's Anemia)

1/2022Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia.
8/2021A homozygous nonsense mutation early in exon 5 of BRCA2 is associated with very severe Fanconi anemia.
1/2019Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.
1/2018Mutational and Functional Analysis of FANCB as a Candidate Gene for Sporadic Head and Neck Squamous Cell Carcinomas.
11/2017FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.
1/2017Stem Cell Genetic Therapy for Fanconi Anemia - A New Hope.
5/2016Fanconi Anemia Proteins Function in Mitophagy and Immunity.
4/2016Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
2/2016Androgen therapy in Fanconi anemia: A retrospective analysis of 30 years in Germany.
4/2015Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.
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Helmut Hanenberg Research Topics

Disease

30Neoplasms (Cancer)
01/2022 - 02/2003
26Fanconi Anemia (Fanconi's Anemia)
01/2022 - 02/2003
11Hypersensitivity (Allergy)
01/2019 - 05/2002
5Hematologic Neoplasms (Hematological Malignancy)
01/2022 - 08/2007
5Leukemia
01/2022 - 04/2004
5Squamous Cell Carcinoma of Head and Neck
01/2022 - 04/2015
5Breast Neoplasms (Breast Cancer)
01/2020 - 02/2003
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 10/2015
4Carcinoma (Carcinomatosis)
01/2021 - 09/2013
4Bone Marrow Failure Disorders
01/2017 - 02/2005
3Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2022 - 08/2007
3Chromosomal Instability (Chromosome Stability)
01/2019 - 02/2003
3Chromosome Breakage
10/2016 - 10/2005
3Hepatocellular Carcinoma (Hepatoma)
09/2013 - 05/2010
3Infections
04/2011 - 03/2008
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
08/2021 - 04/2006
2Neoplasm Metastasis (Metastasis)
01/2021 - 12/2015
2Carcinogenesis
01/2021 - 11/2010
2Graft vs Host Disease (Graft-Versus-Host Disease)
05/2016 - 10/2015
2Head and Neck Neoplasms (Head and Neck Cancer)
04/2016 - 04/2015
2Chromosome Aberrations (Chromosome Abnormalities)
02/2016 - 12/2010
2Adenoma (Adenomas)
02/2016 - 09/2013
2Complementation Group D1 Fanconi Anemia
01/2015 - 02/2003
2Pancytopenia
09/2013 - 04/2006
2Genomic Instability
02/2011 - 12/2004
1Wilms Tumor (Wilm's Tumor)
08/2021
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2021
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2021
1Chromosome Fragility
01/2021
1Fibrosis (Cirrhosis)
10/2020
1Anemia
01/2018
1Ewing Sarcoma (Sarcoma, Ewing)
01/2017
1Renal Cell Carcinoma (Grawitz Tumor)
01/2017
1AIDS-Related Complex (ARC)
01/2017
1Sarcoma (Soft Tissue Sarcoma)
01/2017
1Multiple Myeloma
12/2016
1progressive familial intrahepatic 1 Cholestasis
02/2016
1GATA2 Deficiency
02/2016
1Bone Marrow Diseases (Bone Marrow Disease)
02/2016
1Cytopenia
02/2016
1Virilism (Virilization)
02/2016
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2016

Drug/Important Bio-Agent (IBA)

22DNA (Deoxyribonucleic Acid)IBA
01/2021 - 05/2002
10Proteins (Proteins, Gene)FDA Link
01/2021 - 02/2003
7Chimeric Antigen ReceptorsIBA
01/2022 - 01/2017
4Mitomycin (Mitomycin-C)FDA LinkGeneric
01/2021 - 12/2008
3Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2019
2LigandsIBA
01/2022 - 01/2017
2AntigensIBA
01/2022 - 01/2021
2Nonsense Codon (Nonsense Mutation)IBA
08/2021 - 05/2010
2diepoxybutaneIBA
01/2021 - 10/2005
2Alkylating AgentsIBA
01/2019 - 03/2008
2UbiquitinIBA
01/2019 - 06/2007
2AndrogensIBA
02/2016 - 05/2011
2Phosphotransferases (Kinase)IBA
01/2016 - 09/2005
2enhanced green fluorescent proteinIBA
01/2014 - 03/2008
1Growth Factor ReceptorsIBA
01/2022
1Interleukin-15 (Interleukin 15)IBA
01/2022
1Cetuximab (Erbitux)FDA Link
01/2022
1Monoclonal AntibodiesIBA
01/2022
1Single-Chain AntibodiesIBA
01/2022
1ElementsIBA
01/2022
1DecitabineFDA Link
01/2021
1Protein Isoforms (Isoforms)IBA
01/2021
1romidepsin (FK228)FDA Link
01/2021
1Immune Checkpoint InhibitorsIBA
01/2021
1CytokinesIBA
10/2020
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2020
1NAD (NADH)IBA
01/2020
114,15-epoxy-5,8,11-eicosatrienoic acidIBA
01/2020
1Sirtuin 3IBA
01/2020
1SirtuinsIBA
01/2020
14-ipomeanolIBA
01/2019
1cytochrome P-450 CYP4B1 (CYP4B1)IBA
01/2019
1AldehydesIBA
01/2019
1EnzymesIBA
01/2019
1ProdrugsIBA
01/2019
1gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA
01/2019
1Histone Deacetylase InhibitorsIBA
01/2018
1ErythropoietinFDA Link
01/2018
1Neoplasm Antigens (Tumor Antigens)IBA
01/2017
1Caspase 8 (Caspase-8)IBA
01/2017
1Topotecan (Hycamtin)FDA LinkGeneric
01/2017
1HLA-G Antigens (HLA G)IBA
01/2017
1Cell Adhesion MoleculesIBA
12/2016
1Fanconi Anemia Complementation Group C ProteinIBA
05/2016
1Biomarkers (Surrogate Marker)IBA
05/2016
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2016
1InflammasomesIBA
05/2016
1Member 11 Subfamily B ATP Binding Cassette TransporterIBA
02/2016
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2016
1Carboplatin (JM8)FDA LinkGeneric
12/2015

Therapy/Procedure

12Therapeutics
12/2021 - 03/2008
6Drug Therapy (Chemotherapy)
01/2022 - 04/2006
6Immunotherapy
01/2022 - 01/2020
3Cell Transplantation
05/2016 - 07/2011
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
09/2013 - 04/2004
1Microspheres (Microsphere)
01/2022
1Heterologous Transplantation (Xenotransplantation)
01/2022
1Stem Cell Transplantation
01/2019